The LEP Polyclonal Antibody (PAC016614) is a versatile tool for researchers studying Leptin, a key hormone involved in regulating energy balance and metabolism. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications including Western blot and immunohistochemistry.Leptin, also known as the satiety hormone, plays a crucial role in signaling the brain to regulate appetite and energy expenditure. Dysregulation of leptin signaling has been linked to obesity, diabetes, and other metabolic disorders, making it an important target for therapeutic interventions.
With the ability to detect and quantify leptin in different cell types and tissues, the LEP Polyclonal Antibody is an essential tool for researchers investigating the molecular mechanisms underlying metabolic diseases and exploring potential treatment strategies. Its reliability and specificity make it a valuable asset in the fields of endocrinology, metabolism, and obesity research.
Antibody Name:
LEP Antibody (PACO16614)
Antibody SKU:
PACO16614
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16614(LEP Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
