The LEP Polyclonal Antibody (PAC016613) is a valuable tool for researchers studying LEP, a hormone involved in regulating energy balance and metabolism. This antibody, produced in rabbits, is specifically designed to target LEP in human samples and has been validated for use in Western blot applications. By binding to the LEP protein, this antibody allows for the detection and analysis of LEP in a variety of cell types, making it an essential component for studies in obesity, metabolism, and endocrinology research.LEP, also known as leptin, is a key player in the regulation of body weight, appetite, and energy expenditure. Dysregulation of LEP signaling has been linked to obesity, diabetes, and other metabolic disorders, making it a promising target for therapeutic intervention.
Research into LEP function is essential for understanding the mechanisms underlying these conditions and developing new treatments to address them.Overall, the LEP Polyclonal Antibody is a valuable tool for scientists investigating the role of LEP in metabolism, obesity, and related disorders. Its high reactivity, specificity, and reliability make it ideal for a wide range of research applications, providing essential insights into the complex biology of energy regulation.
Antibody Name:
LEP Antibody (PACO16613)
Antibody SKU:
PACO16613
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16613(LEP Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
