The Lefty1 Polyclonal Antibody (CAB15389) is a valuable tool for studying Lefty1, a member of the TGF-beta superfamily that plays a critical role in embryonic development and cell differentiation. This rabbit polyclonal antibody is highly specific to Lefty1 and is validated for use in various research applications, including Western blot and immunohistochemistry.Lefty1 is known for its ability to regulate cell fate determination during early embryonic development, particularly in establishing the left-right axis. Dysfunction of Lefty1 has been implicated in a variety of developmental abnormalities and diseases, making it a key target for research in developmental biology and regenerative medicine.
By using the Lefty1 Polyclonal Antibody, researchers can accurately detect and analyze Lefty1 expression in different cell types and tissues, providing valuable insights into the mechanisms underlying embryonic development and disease pathology. This antibody is a valuable tool for advancing our understanding of Lefty1 and its implications in various biological processes.
Product Name:
LEFTY1 Rabbit Polyclonal Antibody
SKU:
CAB15389
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 77-366 of human LEFTY1 (NP_066277.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene.
Purification Method:
Affinity purification
Gene ID:
10637
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LEFTY1 Rabbit pAb (CAB15389) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
