The LDOC1 Polyclonal Antibody (PACO03733) is a valuable tool for researchers studying LDOC1, a protein involved in cell cycle regulation and tumor suppression. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot experiments.LDOC1, also known as Leucine Zipper Downregulated in Cancer 1, is implicated in inhibiting cell proliferation and promoting cell differentiation. Its role in tumor suppression suggests a potential therapeutic target for cancer treatment.
By detecting and analyzing LDOC1 protein expression in various cell types, this antibody enables researchers to explore its function in cancer biology and potentially discover novel treatment strategies.The LDOC1 Polyclonal Antibody provides a reliable and accurate method for investigating the molecular mechanisms underlying LDOC1's tumor suppressive effects. With its versatility and precision, this antibody is an essential tool for advancing our understanding of cancer biology and developing innovative therapies for cancer patients.
Antibody Name:
LDOC1 Antibody
Antibody SKU:
PACO03733
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human LDOC1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
LDOC1; BCUR1; Protein LDOC1; Leucine zipper protein down-regulated in cancer cells
UniProt Protein Function:
LDOC1: May have an important role in the development and/or progression of some cancers. Belongs to the LDOC1 family.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: Xq27Cellular Component: nucleolus; nucleusMolecular Function: protein bindingBiological Process: negative regulation of cell proliferation
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
