The LDLRAP1 Polyclonal Antibody (CAB7093) is a valuable tool for researchers studying LDLRAP1, a protein involved in the regulation of cholesterol metabolism and the endocytosis of low-density lipoprotein (LDL) particles. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications, enabling the detection and analysis of LDLRAP1 in a variety of cell types.LDLRAP1 plays a crucial role in the cellular uptake of LDL particles, a process essential for maintaining cholesterol homeostasis in the body.
Dysregulation of LDLRAlP1 has been linked to hypercholesterolemia and cardiovascular diseases, making it a promising target for research in lipid metabolism and cardiovascular health. By understanding the function of LDLRAP1, researchers can gain insights into the mechanisms underlying these diseases and develop new therapeutic strategies for treating them.
Product Name:
LDLRAP1 Rabbit Polyclonal Antibody
SKU:
CAB7093
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 59-308 of human LDLRAP1 (NP_056442.2).
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
Purification Method:
Affinity purification
Gene ID:
26119
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LDLRAP1 antibody (CAB7093) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
