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LDHA Polyclonal Antibody (CAB21741)

SKU:
CAB21741
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
€129 - €359
Frequently bought together:

Description

LDHA Polyclonal Antibody (CAB21741)

The LDHA Polyclonal Antibody (CAB21741) is a valuable tool for researchers studying lactate dehydrogenase A (LDHA), an enzyme involved in the conversion of pyruvate to lactate in the glycolysis pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.LDHA is a key player in metabolic reprogramming, a hallmark of cancer cells that allows them to thrive in low oxygen environments. By targeting LDHA with this antibody, researchers can better understand the role of this enzyme in cancer progression and potentially identify new therapeutic targets for cancer treatment.

The LDHA Polyclonal Antibody is an essential tool for researchers in the fields of oncology, metabolism, and biochemistry. Its specificity for LDHA protein enables accurate detection and analysis in a variety of cell types, making it a versatile asset in the study of cancer biology and metabolic diseases.

Product Name:LDHA Polyclonal Antibody
Product Code:CAB21741
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:1000-1:5000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa
Cellular Location:Cytoplasm

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-332 of human LDHA (NP_005557.1).
Sequence:MATLK DQLIY NLLKE EQTPQ NKITV VGVGA VGMAC AISIL MKDLA DELAL VDVIE DKLKG EMMDL QHGSL FLRTP KIVSG KDYNV TANSK LVIIT AGARQ QEGES RLNLV QRNVN IFKFI IPNVV KYSPN CKLLI VSNPV DILTY VAWKI SGFPK NRVIG SGCNL DSARF RYLMG ERLGV HPLSC HGWVL GEHGD SSVPV WSGMN VAGVS LKTLH PDLGT DKDKE QWKEV HKQVV ESAYE VIKLK GYTSW AIGLS VADLA ESIMK NLRRV HPVST MIKGL YGIKD DVFLS VPCIL GQNGI SDLVK VTLTS EEEAR LKKSA DTLWG IQKEL QF
Synonyms:LDHM, GSD11, PIG19, HEL-S-133P
Calculated MW:37kDa
Observed MW:37kDa

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