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LDHA Monoclonal Antibody [PAT1A4AT] (CPAB0093)

SKU:
CPAB0093
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT1A4AT
Applications:
WB
IF
ELISA
€149
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Description

system_update_alt Datasheet

LDHA Monoclonal Antibody [PAT1A4AT] (CPAB0093)

The LDHA Polyclonal Antibody (CPAB0093) is a valuable tool for researchers studying LDHA, an enzyme that plays a key role in the glycolysis pathway. This antibody, generated in rabbits, is highly specific to human LDHA and is validated for use in Western blot applications. By targeting the LDHA protein, this antibody allows for the detection and analysis of LDHA levels in a variety of cell types, making it ideal for investigations in cancer biology and metabolism research.LDHA is essential for converting pyruvate into lactate during anaerobic metabolism, a process that is often upregulated in cancer cells to meet their energy demands.

By studying LDHA expression and activity, researchers can gain insights into the metabolic adaptations of cancer cells and explore potential therapeutic targets for cancer treatment. The LDHA Polyclonal Antibody is a valuable tool for advancing our understanding of cancer metabolism and developing new strategies for cancer therapy.

Product Name:LDHA Antibody
Product Sku:CPAB0093
Size:5μg
Host Species:Mouse
Immunogen:Anti-human LDHA mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LDHA amino acids 1-332 purified from Ecoli.
Clone:PAT1A4AT.
Reactivity:Human
Applications:Western Blot, Immunofluorescence, ELISA
Purification Method:LDHA antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA is localized primarily in muscle tissue and is part of the lactate dehydrogenase family. Mutations in LDHA have been linked to exertional myoglobinuria. LDH1 is decreased in essential thrombocythemia. LDHA is induced through a non-genomic pathway of estrogen action. Reduction in LDH-A activity results in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential.
Synonyms:LDH-A, GSD11, LDH1, LDHM, PIG19, EC 1.1.1.27, lactate dehydrogenase M, LDH-M, LDH-1, L-lactate dehydrogenase A chain, LDH muscle subunit, Renal carcinoma antigen NY-REN-59, Cell proliferation-inducing gene 19 protein, LDHA.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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