UniProt Protein Function: | Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso-Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc-anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross-linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks; LcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase. |
UniProt Protein Details: | |
NCBI Summary: | LdcA mutants can lyse in stationary phase (Templin, 1999; Herve, 2007). [More information is available at EcoGene: EG13898]. LdcA is an L,D-carboxypeptidase that has an essential function in murein (peptidoglycan) recycling/turnover . [More information is available at EcoCyc: G6621]. |
UniProt Code: | P76008 |
NCBI GenInfo Identifier: | 16129155 |
NCBI Gene ID: | 945756 |
NCBI Accession: | NP_415710.1 |
UniProt Secondary Accession: | P76008,O87499 |
UniProt Related Accession: | P76008 |
Molecular Weight: | |
NCBI Full Name: | murein tetrapeptide carboxypeptidase; LD-carboxypeptidase A |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | ldcAÂ Â |
NCBI Official Synonym Symbols: | ECK1180; JW1181; ycgQÂ Â |
NCBI Protein Information: | murein tetrapeptide carboxypeptidase; LD-carboxypeptidase A |
UniProt Protein Name: | Murein tetrapeptide carboxypeptidase |
UniProt Synonym Protein Names: | LD-carboxypeptidase A; Muramoyltetrapeptide carboxypeptidase |
Protein Family: | Murein tetrapeptide carboxypeptidase |
UniProt Gene Name: | ldcAÂ Â |
UniProt Entry Name: | LDCA_ECOLI |