The LDCA Antibody (PACO34016) is a highly specific polyclonal antibody designed for research involving LDCA, a key molecule involved in immune regulation and inflammation. This antibody, generated in rabbits, is reactive with human samples and has been validated for use in Western blot applications. By binding to the LDCA protein, this antibody enables accurate detection and analysis in various cell types, making it an invaluable tool for studies in immunology and cancer research.LDCA, also known as an immune modulatory molecule, plays a critical role in immune response modulation by regulating inflammation and inhibiting allergic reactions.
Its importance in immune homeostasis makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the functions of LDCA is essential for the development of therapeutic strategies that manipulate immune responses in these pathological contexts.Overall, the LDCA Antibody (PACO34016) is a powerful tool for researchers studying immune regulation, inflammation, and related diseases, offering high specificity and sensitivity in detecting LDCA protein in various experimental settings.
Antibody Name:
ldcA Antibody (PACO34016)
Antibody SKU:
PACO34016
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Murein tetrapeptide carboxypeptidase protein (1-304AA)
Form:
Liquid
Storage Buffer:
Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2
Purification Method:
>95%, Protein G purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Background:
Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso-Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc-anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross-linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks; LcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase.
Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso-Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc-anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross-linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks; LcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase.
UniProt Protein Details:
NCBI Summary:
LdcA mutants can lyse in stationary phase (Templin, 1999; Herve, 2007). [More information is available at EcoGene: EG13898]. LdcA is an L,D-carboxypeptidase that has an essential function in murein (peptidoglycan) recycling/turnover . [More information is available at EcoCyc: G6621].
