The LDB2 Polyclonal Antibody (CAB10472) is a valuable tool for research involving LDB2, a transcription factor involved in various biological processes such as cell differentiation, development, and disease pathogenesis. Raised in rabbits, this antibody is highly specific to human samples and is validated for use in applications such as Western blotting. By binding to the LDB2 protein, this antibody enables detection and analysis in different cell types, making it an essential resource for studies in molecular biology and disease research.LDB2, also known as LIM domain-binding protein 2, plays a crucial role in gene regulation and transcriptional activation, making it a key player in various cellular functions.
Its involvement in pathways related to cell growth, differentiation, and survival highlights its importance in understanding disease mechanisms, particularly in cancer and developmental disorders. By targeting LDB2, researchers can gain insights into the molecular pathways underlying these conditions, paving the way for the development of targeted therapies and interventions.
Product Name:
LDB2 Rabbit Polyclonal Antibody
SKU:
CAB10472
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 204-373 of human LDB2 (NP_001281.1).
The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9079
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LDB2 antibody (CAB10472) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
