The Anti-L-Plastin (LCP1) Antibody (CAB4664) is a valuable tool for researchers studying L-Plastin, a cytoskeleton protein involved in cell migration and adhesion. This antibody, produced in rabbit, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the L-Plastin protein, this antibody enables the detection and analysis of L-Plastin expression in various cell types, making it an essential component in studies related to cell motility, cancer metastasis, and immune cell function.L-Plastin, also known as LCP1, plays a crucial role in the regulation of actin dynamics and cell shape changes, making it an important factor in processes like cell migration and invasion.
Dysregulation of L-Plastin expression has been linked to various diseases, including cancer and autoimmune disorders, making it a promising target for therapeutic interventions. By understanding the function and regulation of L-Plastin using this antibody, researchers can gain valuable insights into the mechanisms underlying disease progression and potential treatment strategies.
Product Name:
Plastin L Rabbit Monoclonal Antibody
SKU:
CAB4664
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 528-627 of human L-Plastin/LCP1 (P13796).
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
Purification Method:
Affinity purification
Gene ID:
3936
Clone Number:
ARC2689
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Raji cells, using L-Plastin/LCP1 Rabbit mAb (CAB4664) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
