The LCOR Antibody (PACO10211) is a high-quality polyclonal antibody designed for research involving LCOR, a protein involved in gene regulation and transcriptional activation. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blot and immunohistochemistry.LCOR, also known as Ligand-Dependent Nuclear Receptor Corepressor, plays a crucial role in regulating gene expression and mediating transcriptional repression. Its involvement in signaling pathways and chromatin remodeling makes it a key player in the regulation of cell growth, differentiation, and development.
The LCOR Antibody binds specifically to the LCOR protein, allowing for precise detection and analysis in different cell types.Researchers in the fields of molecular biology, cell biology, and cancer research can benefit from the use of the LCOR Antibody in their studies. By understanding the function and regulation of LCOR, scientists can gain insights into various biological processes and potentially identify targets for therapeutic interventions in diseases such as cancer and neurodegenerative disorders. Invest in the LCOR Antibody to advance your research and uncover new discoveries in gene regulation and transcriptional control.
LCOR: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 10q24Cellular Component: nucleusMolecular Function: DNA binding; transcription factor activity; transcription factor bindingBiological Process: transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
