UniProt Protein Function: | LCOR: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 10q24Cellular Component: nucleusMolecular Function: DNA binding; transcription factor activity; transcription factor bindingBiological Process: transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter |
UniProt Protein Details: | |
NCBI Summary: | LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q96JN0 |
NCBI GenInfo Identifier: | 282847508 |
NCBI Gene ID: | 84458 |
NCBI Accession: | NP_115816.2 |
UniProt Secondary Accession: | Q96JN0,Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6, D3DR47 |
UniProt Related Accession: | Q96JN0 |
Molecular Weight: | 44,083 Da |
NCBI Full Name: | ligand-dependent corepressor isoform 1 |
NCBI Synonym Full Names: | ligand dependent nuclear receptor corepressor |
NCBI Official Symbol: | LCORÂ Â |
NCBI Official Synonym Symbols: | MLR2Â Â |
NCBI Protein Information: | ligand-dependent corepressor; mblk1-related protein 2 |
UniProt Protein Name: | Ligand-dependent corepressor |
UniProt Synonym Protein Names: | Mblk1-related protein 2 |
Protein Family: | Ligand-dependent corepressor |
UniProt Gene Name: | LCORÂ Â |
UniProt Entry Name: | LCOR_HUMAN |