The LCN2 Polyclonal Antibody (CAB2092) is specifically designed for research involving Lipocalin-2 (LCN2), a protein known for its role in various physiological and pathological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the LCN2 protein, researchers can detect and analyze its presence in different cell types, making it an ideal tool for studies in immunology, cancer research, and beyond.
LCN2, also known as neutrophil gelatinase-associated lipocalin (NGAL), is involved in diverse functions such as iron transport, inflammation regulation, and cell survival. Its implication in various diseases like cancer, diabetes, and kidney injury highlights the importance of studying LCN2 and its role in these pathological conditions. By understanding the mechanisms of LCN2, researchers can potentially develop targeted therapies for treating these diseases and improving patient outcomes.
Product Name:
Lipocalin-2/NGAL Rabbit Polyclonal Antibody
SKU:
CAB2092
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-198 of human Lipocalin-2/NGAL (NP_005555.2).
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice.
Purification Method:
Affinity purification
Gene ID:
3934
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Lipocalin-2/NGAL Rabbit pAb (CAB2092) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
