The LCMT1 Monoclonal Antibody (PACO16609) is specifically designed for research involving LCMT1, a crucial enzyme involved in protein methylation and cellular processes. This antibody, generated using a unique monoclonal approach, exhibits high specificity and sensitivity for LCMT1 in human samples, making it an ideal tool for various experimental applications.LCMT1, also known as leucine carboxyl methyltransferase 1, is a key player in the regulation of protein function through methylation, impacting critical cellular processes such as gene expression, signal transduction, and protein stability.
This antibody enables precise detection and analysis of LCMT1 expression in different cell types, facilitating in-depth investigations in molecular biology, biochemistry, and cell signaling studies.The role of LCMT1 in protein methylation pathways makes it a promising target for research in various fields, including cancer biology, neuroscience, and metabolic disorders. By understanding the functions and regulation of LCMT1, researchers can uncover new insights into disease mechanisms and potentially identify novel therapeutic strategies for treating related conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16609(LCMT1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: PACO16609(LCMT1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16609(LCMT1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A.
Synonyms:
leucine carboxyl methyltransferase 1
UniProt Protein Function:
LCMT1: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine; EC 2.1.1.233; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acidChromosomal Location of Human Ortholog: 16p12.1Cellular Component: cytosolMolecular Function: protein binding; C-terminal protein carboxyl methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activityBiological Process: regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; protein modification process; negative regulation of protein complex assembly
UniProt Protein Details:
NCBI Summary:
LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
