LCMT1 Antibody (PACO16609)
- SKU:
- PACO16609
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | LCMT1 Antibody (PACO16609) |
| Antibody SKU: | PACO16609 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Fusion protein of human LCMT1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16609(LCMT1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: PACO16609(LCMT1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16609(LCMT1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A. |
| Synonyms: | leucine carboxyl methyltransferase 1 |
| UniProt Protein Function: | LCMT1: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine; EC 2.1.1.233; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acidChromosomal Location of Human Ortholog: 16p12.1Cellular Component: cytosolMolecular Function: protein binding; C-terminal protein carboxyl methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activityBiological Process: regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; protein modification process; negative regulation of protein complex assembly |
| UniProt Protein Details: | |
| NCBI Summary: | LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9UIC8 |
| NCBI GenInfo Identifier: | 74048545 |
| NCBI Gene ID: | 51451 |
| NCBI Accession: | NP_001027563.1 |
| UniProt Secondary Accession: | Q9UIC8,Q53FC5, Q96CI5, Q9H6I9, Q9NTG4, Q9Y378, A6NL89 A8K770 |
| UniProt Related Accession: | Q9UIC8 |
| Molecular Weight: | 32,172 Da |
| NCBI Full Name: | leucine carboxyl methyltransferase 1 isoform b |
| NCBI Synonym Full Names: | leucine carboxyl methyltransferase 1 |
| NCBI Official Symbol: | LCMT1Â Â |
| NCBI Official Synonym Symbols: | LCMT; PPMT1; CGI-68Â Â |
| NCBI Protein Information: | leucine carboxyl methyltransferase 1; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; protein phosphatase methyltransferase 1; protein-leucine O-methyltransferase |
| UniProt Protein Name: | Leucine carboxyl methyltransferase 1 |
| UniProt Synonym Protein Names: | Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 |
| Protein Family: | Leucine carboxyl methyltransferase |
| UniProt Gene Name: | LCMT1Â Â |
| UniProt Entry Name: | LCMT1_HUMAN |
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