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LCK Rabbit Polyclonal Antibody (CAB2177)

SKU:
CAB2177
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-LCK Antibody CAB2177
  • Immunology Antibodies 2 Anti-LCK Antibody CAB2177
  • Immunology Antibodies 2 Anti-LCK Antibody CAB2177
  • Immunology Antibodies 2 Anti-LCK Antibody CAB2177
  • Immunology Antibodies 2 Anti-LCK Antibody CAB2177
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:LCK Rabbit Polyclonal Antibody
SKU:CAB2177
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human LCK (NP_005347.3).
Sequence:MGCG CSSH PEDD WMEN IDVC ENCH YPIV PLDG KGTL LIRN GSEV RDPL VTYE GSNP PASP LQDN LVIA LHSY EPSH DGDL GFEK GEQL RILE QSGE WWKA QSLT TGQE GFIP FNFV AKAN SLEP EPWF FKNL SRKD AERQ LLAP GNTH GSFL IRES ESTA GSFS LSVR DFDQ NQGE VVKH YKIR NLDN GGFY ISPR ITFP GLHE LVRH YTNA SDGL CTRL SRPC QTQK PQKP WWED EWEV
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:LSK; YT16; IMD22; p56lck; pp58lck; LCK
Positive Sample:Raji,Mouse lung,Mouse thymus
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor.
Calculated MW:58kDa
Observed MW:58kDa

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.

Purification Method:Affinity purification
Gene ID:3932
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse thymus, using LCK Rabbit pAb (CAB2177) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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