The LCAT Polyclonal Antibody (CAB11741) is a valuable tool for researchers studying LCAT, an enzyme involved in lipid metabolism and cholesterol esterification. This antibody, produced in rabbits, is specifically designed for use with human samples and has been validated for Western blot applications. By binding to the LCAT protein, this antibody allows for the detection and analysis of LCAT expression in various cell types, making it essential for studies in lipid metabolism, cardiovascular disease, and lipid-related disorders.LCAT, or lecithin-cholesterol acyltransferase, is a key player in the process of cholesterol esterification, playing a crucial role in reverse cholesterol transport and maintaining cholesterol homeostasis.
Dysregulation of LCAT activity has been linked to lipid disorders, atherosclerosis, and cardiovascular diseases, highlighting the importance of studying this enzyme in both health and disease. The LCAT Polyclonal Antibody provides researchers with a powerful tool to further understand the function and regulation of LCAT in various physiological and pathological conditions.
Product Name:
LCAT Rabbit Polyclonal Antibody
SKU:
CAB11741
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-440 of human LCAT (NP_000220.1).
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.
Purification Method:
Affinity purification
Gene ID:
3931
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using LCAT Rabbit pAb (CAB11741) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
