The LCA5 Polyclonal Antibody (PAC037306) is a valuable tool for researchers studying LCA5, a protein involved in Leber congenital amaurosis, a rare genetic disorder that causes severe vision loss in early childhood. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the LCA5 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in ophthalmology and genetics research.
Understanding the function of LCA5 is essential for developing potential therapies to treat or prevent Leber congenital amaurosis and other related retinal diseases.The LCA5 Polyclonal Antibody is a reliable tool for investigating the role of LCA5 in vision and retinal development, providing valuable insights into the molecular mechanisms underlying genetic eye disorders. Researchers can use this antibody to explore potential treatment options and further our understanding of the pathophysiology of Leber congenital amaurosis.
Western blot. All lanes: LCA5 antibody at 18µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 81 kDa. Observed band size: 81 kDa.
Background:
Might be involved in minus end-directed microtubule transport.
LCA5: Might be involved in minus end-directed microtubule transport. Defects in LCA5 are the cause of Leber congenital amaurosis type 5 (LCA5). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Belongs to the LCA5 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 6q14.1Cellular Component: axoneme; ciliumMolecular Function: protein binding; protein complex bindingBiological Process: intraflagellar transport; photoreceptor cell maintenanceDisease: Leber Congenital Amaurosis 5
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternatively spliced transcript variants are described. [provided by RefSeq, Oct 2009]
