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LC3B Polyclonal Antibody (CAB19434)

SKU:
CAB19434
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
IHC
€139 - €609
Frequently bought together:

Description

LC3B Polyclonal Antibody (CAB19434)

The LC3B Polyclonal Antibody (CAB19434) is a valuable tool for researchers studying autophagy, a cellular process involved in the degradation and recycling of cellular components. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunofluorescence applications.LC3B is a key protein involved in the formation of autophagosomes, the double-membrane vesicles responsible for sequestering cellular material for degradation. Dysregulation of autophagy has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions.

By targeting LC3B, researchers can investigate the role of autophagy in these diseases and potentially develop new therapeutic strategies.The LC3B Polyclonal Antibody enables the detection and analysis of LC3B protein levels in different cell types, providing valuable insights into the regulation of autophagy and its impact on cellular homeostasis. By understanding the mechanisms underlying autophagy, researchers can uncover novel targets for intervention and potentially improve treatment outcomes for a range of diseases.

Product Name:LC3B Polyclonal Antibody
Product Code:CAB19434
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence, Immunohistochemistry
Recommended Dilution:WB 1:500-1:2000, IF/ICC 1:50-1:200, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:Rat brain
Cellular Location:Cytoplasm, Cytoplasmic vesicle, Endomembrane system, Lipid-anchor, autophagosome, autophagosome membrane, cytoskeleton

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LC3B (NP_073729.1).
Sequence:MPSEK TFKQR RTFEQ RVEDV RLIRE QHPTK IPVII ERYKG EKQLP VLDKT KFLVP DHVNM SELIK IIRRR LQLNA NQAFF LLVNG HSMVS VSTPI SEVYE
Synonyms:LC3B, ATG8F, MAP1LC3B-a, MAP1A/1BLC3
Calculated MW:15kDa
Observed MW:15kDa

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