The LBP Polyclonal Antibody (PACO64287) is a valuable tool for researchers studying Lipopolysaccharide Binding Protein (LBP), an important component of the innate immune response. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.LBP plays a crucial role in the recognition and response to bacterial infections, specifically by binding to bacterial lipopolysaccharides and initiating the immune response. By targeting LBP, researchers can study the mechanisms underlying immune activation and inflammatory processes, making this antibody ideal for studies in infectious diseases, inflammation, and immune system disorders.
Understanding the function of LBP is essential for developing new therapies and treatments for conditions related to bacterial infections and inflammatory diseases. The LBP Polyclonal Antibody provides a reliable tool for detecting and analyzing LBP expression in various cell types, advancing research efforts in immunology and infectious disease studies.
Antibody Name:
Lbp Antibody (PACO64287)
Antibody SKU:
PACO64287
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:200-1:500
Species Reactivity:
Rat
Immunogen:
Peptide sequence from Rat Lipopolysaccharide-binding protein (250-264AA)
IHC image of PACO64287 diluted at 1:300 and staining in paraffin-embedded Rat kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Background:
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
Synonyms:
Lipopolysaccharide-binding protein (LBP), Lbp
UniProt Protein Function:
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
NCBI Summary:
binds lipopolysaccharide on outer membrane of gram negative bacteria; involved in immune response [RGD, Feb 2006]
