LATS2 Rabbit Polyclonal Antibody (CAB16249)
- SKU:
- CAB16249
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | LATS2 Rabbit Polyclonal Antibody |
SKU: | CAB16249 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-145 of human LATS2 (NP_055387.2). |
Sequence: | FGPY QKAL REIR YSLL PFAN ESGT SAAA EVNR QMLQ ELVN AGCD QEMA GRAL KQTG SRSI EAAL EYIS KMGY LDPR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | KPM; LATS2 |
Positive Sample: | Mouse testis,Rat lung,Rat testis,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle pole. |
Calculated MW: | 120kDa |
Observed MW: | 150kDa |
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
Purification Method: | Affinity purification |
Gene ID: | 26524 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |