The LATS1 Polyclonal Antibody (CAB17992) is a vital tool for researchers studying LATS1, a tumor suppressor gene involved in controlling cell growth and division. This rabbit-derived antibody is highly specific to human samples and has been extensively validated for Western blot applications. By targeting the LATS1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in cancer biology and cell cycle regulation.LATS1, a key component of the Hippo signaling pathway, plays a crucial role in inhibiting cell proliferation and promoting apoptosis.
Dysregulation of LATS1 has been implicated in various cancers, making it a potential therapeutic target for cancer treatment. Furthermore, understanding the role of LATS1 in cell growth control is essential for developing new strategies for cancer therapy and personalized medicine.Overall, the LATS1 Polyclonal Antibody is a valuable tool for researchers looking to explore the molecular mechanisms underlying cancer development and progression. Its high specificity and reliability make it a must-have for any laboratory conducting research in the fields of oncology and cell biology.
Product Name:
LATS1 Rabbit Polyclonal Antibody
SKU:
CAB17992
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human LATS1 (NP_004681.1).
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Purification Method:
Affinity purification
Gene ID:
9113
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LATS1 Rabbit pAb (CAB17992) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
