The LAT2 Polyclonal Antibody (PAC014639) is a powerful tool for researchers studying LAT2, a protein involved in immune regulation and cell signaling. This antibody, developed using rabbit immunization, exhibits high specificity and sensitivity for detecting LAT2 in human samples, making it an ideal choice for Western blotting applications.LAT2, also known as linker for activation of T cells family member 2, is crucial for T cell activation and function by facilitating signal transduction processes. Its role in immune response regulation makes it a promising target for research in immunology and cancer biology. By using the LAT2 Polyclonal Antibody, scientists can confidently study the expression and localization of LAT2 in different cell types, aiding in the understanding of its functions in health and disease.
With its high reactivity and reliability in Western blotting, the LAT2 Polyclonal Antibody provides a valuable tool for investigating the role of LAT2 in immune responses, inflammation, and disease progression. Researchers can utilize this antibody to advance their studies in immunology, cancer research, and therapeutic development, ultimately contributing to the discovery of novel treatments for various immune-related disorders.
Antibody Name:
LAT2 Antibody (PACO14639)
Antibody SKU:
PACO14639
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human LAT2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14639(LAT2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin γ Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Synonyms:
linker for activation of T cells family, member 2
UniProt Protein Function:
LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.
UniProt Protein Details:
Protein type:Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft
Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation
NCBI Summary:
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]
linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2
UniProt Protein Name:
Linker for activation of T-cells family member 2
UniProt Synonym Protein Names:
Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein
