The LASA Antibody (PAC034142) is a polyclonal antibody designed for research involving LASA, a protein involved in immune regulation and immune response modulation. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in a variety of applications, including Western blotting. LASA, also known as a key player in immune homeostasis, plays a critical role in regulating inflammation and inhibiting allergic reactions. Its importance in immune function makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
The LASA Antibody enables the detection and analysis of the LASA protein in various cell types, making it an ideal tool for studies in immunology and cancer research. Understanding the activity of LASA is essential for the development of therapies that can harness or modulate immune function in these disease contexts.
Antibody Name:
lasA Antibody (PACO34142)
Antibody SKU:
PACO34142
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Pseudomonas aeruginosa
Immunogen:
Recombinant Pseudomonas aeruginosa Protease LasA protein (237-418AA)
Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly- |-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate.
Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly-|-X substrates where X is Ala or Gly (PubMed:11179971). Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases (PubMed:2110137). Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate (PubMed:20026068).
