The LARS2 Polyclonal Antibody (PAC044950) is a cutting-edge tool designed for researchers investigating LARS2, a mitochondrial leucyl-tRNA synthetase enzyme involved in protein synthesis within the mitochondria. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting LARS2 in human samples, making it an ideal choice for Western blotting applications.LARS2 is a critical enzyme in cellular function, playing a key role in translating genetic information into functional proteins essential for mitochondrial activity. Dysregulation of LARS2 has been linked to various diseases, including neurodegenerative disorders and mitochondrial dysfunction.
By utilizing the LARS2 Polyclonal Antibody, researchers can explore the role of LARS2 in these pathologies and potentially uncover new therapeutic targets for treating these conditions.With its high reactivity and reliability in detecting LARS2 protein expression, the PAC044950 antibody is a valuable tool for researchers in the fields of molecular biology, genetics, and mitochondrial research. By elucidating the functions and mechanisms of LARS2, scientists can gain insights into mitochondrial biology and its implications for human health and disease.
Antibody Name:
LARS2 Antibody (PACO44950)
Antibody SKU:
PACO44950
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Probable leucine--tRNA ligase, mitochondrial protein (1-250AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human colon cancer using PACO44950 at dilution of 1:100.
Background:
mitochondrial matrix, mitochondrion, leucine-tRNA ligase activity, leucyl-tRNA aminoacylation, tRNA aminoacylation for protein translation
LARS2: a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]Protein type: Translation; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Mitochondrial; Ligase; EC 6.1.1.4Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: mitochondrion; mitochondrial matrix; cytosolMolecular Function: leucine-tRNA ligase activity; ATP bindingBiological Process: leucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; regulation of translational fidelity; gene expressionDisease: Perrault Syndrome 4
UniProt Protein Details:
NCBI Summary:
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
