The LARS Polyclonal Antibody (CAB14890) is specifically designed for research involving Leucyl-tRNA Synthetase (LARS), an enzyme responsible for catalyzing the attachment of leucine to its cognate tRNA during protein synthesis. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the LARS protein, researchers can effectively detect and analyze its expression in various cell types.LARS is a critical enzyme in the process of protein synthesis, and disruptions in its regulation have been implicated in various diseases, including cancer and neurodegenerative disorders.
Understanding the role of LARS can provide valuable insights into the mechanisms underlying these diseases and may lead to the development of targeted therapies.By utilizing the LARS Polyclonal Antibody in their studies, researchers can gain a deeper understanding of the functions and dysregulation of LARS in different pathological states. This antibody is an essential tool for investigations in the fields of molecular biology, biochemistry, and disease research.
Product Name:
LARS Rabbit Polyclonal Antibody
SKU:
CAB14890
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LARS (NP_064502.9).
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed.
Purification Method:
Affinity purification
Gene ID:
51520
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LARS Rabbit pAb (CAB14890) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
