The Lanosterol Synthase Polyclonal Antibody (CAB6930) is a valuable tool for researchers studying lanosterol synthase, a key enzyme in the cholesterol synthesis pathway. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting lanosterol synthase in human samples, making it ideal for use in Western blot applications. By targeting the lanosterol synthase protein, this antibody allows for precise detection and analysis in a variety of cell types, enabling insights into cholesterol metabolism and its implications in diseases such as atherosclerosis and metabolic disorders.
Lanosterol synthase is an essential enzyme involved in the conversion of 2,3-oxidosqualene to lanosterol, a precursor of cholesterol. Dysregulation of this pathway has been linked to dyslipidemia, cardiovascular disease, and other metabolic disorders. By utilizing the CAB6930 antibody, researchers can further investigate the role of lanosterol synthase in these conditions, potentially uncovering new therapeutic targets for intervention. This antibody is a valuable asset for studies focused on cholesterol metabolism and its impact on human health.
Product Name:
LSS Rabbit Polyclonal Antibody
SKU:
CAB6930
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3).
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4047
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using LSS antibody (CAB6930) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
