The LANCL2 Polyclonal Antibody (PAC058476) is a valuable tool for researchers studying LANCL2, a protein involved in immune regulation and inflammation. Raised in rabbits, this antibody has high reactivity with human samples and is validated for use in Western blot applications. By binding to LANCL2 protein, this antibody allows for the detection and analysis of LANCL2 in various cell types, making it ideal for studies in immunology and inflammatory diseases.LANCL2, also known as immune modulatory receptor, plays a critical role in immune response regulation by modulating inflammation and immune cell activation.
Its significance in immune function makes it a promising target for research into diseases such as autoimmune disorders, inflammatory conditions, and cancer. Understanding the function of LANCL2 is essential for developing new therapies that target the immune response in these disease contexts.Overall, the LANCL2 Polyclonal Antibody is a valuable tool for researchers interested in studying immune regulation and inflammatory pathways, with the potential to advance our understanding of immune-related diseases and guide the development of novel therapeutic strategies.
Western Blot. Positive WB detected in: A549 whole cell lysate, U87 whole cell lysate. All lanes: LANCL2 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51 kDa. Observed band size: 51 kDa.
Immunofluorescence staining of HepG2 cells with PACO58476 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO58476 diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Necessary for abscisic acid, (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Synonyms:
LanC-like protein 2 (Testis-specific adriamycin sensitivity protein), LANCL2, GPR69B TASP
UniProt Protein Function:
LANCL2: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Belongs to the LanC-like protein family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7q31.1-q31.33Cellular Component: cortical actin cytoskeleton; cytoplasm; cytosol; nucleus; plasma membraneMolecular Function: ATP binding; catalytic activity; GTP binding; phosphatidylinositol 3-phosphate binding; phosphatidylinositol-5-phosphate binding; protein bindingBiological Process: metabolic process; negative regulation of transcription, DNA-dependent; positive regulation of abscisic acid mediated signaling
