The LAMTOR1 Polyclonal Antibody (AB10037) is a valuable tool for researchers studying the LAMTOR1 protein, a key component of the Ragulator complex involved in lysosomal positioning and nutrient sensing pathways. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.LAMTOR1, also known as p18, is crucial for the proper functioning of the Ragulator complex, which regulates the activity of the mTORC1 signaling pathway. Dysregulation of this pathway has been linked to various diseases, including cancer, metabolic disorders, and neurodegenerative conditions.
By targeting LAMTOR1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.The LAMTOR1 Polyclonal Antibody enables the detection and analysis of LAMTOR1 protein levels in different cell types, making it ideal for studies in cell biology, cancer research, and metabolic disorders. Understanding the role of LAMTOR1 in cellular signaling pathways is essential for advancing our knowledge of disease pathogenesis and exploring novel treatment strategies.
Product Name:
LAMTOR1 Polyclonal Antibody
SKU:
CAB21557
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LAMTOR1 (NP_060377.1).
Cell membrane, Cytoplasmic side, Late endosome membrane, Lipid-anchor, Lysosome membrane.
Calculated MW:
18kDa
Observed MW:
Refer to figures
Enables GTPase binding activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TOR signaling; and regulation of cholesterol transport. Located in lysosome. Part of Ragulator complex.
Purification Method:
Affinity purification
Gene ID:
55004
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LAMTOR1 Rabbit pAb (CAB21557) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
