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Anti-LAMP2a Antibody (CAB0593)

SKU:
CAB0593
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Autophagy
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-LAMP2a Antibody
Antibody SKU:CAB0593
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human LAMP2a
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, Mouse liver, Mouse kidney, Rat liver, Rat kidney
Immunogen:A synthesized peptide derived from human LAMP2a
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3920
Uniprot:P13473
Cellular Location:
Calculated MW:120kDa
Observed MW:100KDa
Anti-LAMP2a AntibodyWestern blot - LAMP2a Rabbit mAb (CAB0593)
Synonyms:CD107b, LAMP-2, LAMPB, LGP-96, LGP110
Background:The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
UniProt Protein Function:LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: phagocytic vesicle membrane; membrane; lysosome; lysosomal membrane; late endosome membrane; late endosome; plasma membrane; integral to membrane; platelet dense granule membrane

Molecular Function:protein domain specific binding; enzyme binding

Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation

Disease: Danon Disease

NCBI Summary:The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
UniProt Code:P13473
NCBI GenInfo Identifier:1708854
NCBI Gene ID:3920
NCBI Accession:P13473.2
UniProt Secondary Accession:P13473,Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93, A8K4X5 D3DTF0,
UniProt Related Accession:P13473
Molecular Weight:410
NCBI Full Name:Lysosome-associated membrane glycoprotein 2
NCBI Synonym Full Names:lysosomal-associated membrane protein 2
NCBI Official Symbol:LAMP2  
NCBI Official Synonym Symbols:LAMPB; CD107b; LAMP-2; LGP110  
NCBI Protein Information:lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B
UniProt Protein Name:Lysosome-associated membrane glycoprotein 2
UniProt Synonym Protein Names:CD107 antigen-like family member B; CD_antigen: CD107b
Protein Family:Lysosome-associated membrane glycoprotein
UniProt Gene Name:LAMP2  
UniProt Entry Name:LAMP2_HUMAN

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