The LAMP2 Polyclonal Antibody (CAB14017) is a key tool for researchers studying lysosomal-associated membrane protein 2 (LAMP2), a critical component of lysosomal function and autophagy. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot. By binding specifically to the LAMP2 protein, this antibody enables accurate detection and analysis of lysosomal activity in different cell types, making it an essential tool for studies in cell biology, metabolism, and neurodegenerative diseases.LAMP2 plays a crucial role in maintaining cellular homeostasis by regulating lysosome function and promoting the degradation of cellular waste through autophagy.
Dysregulation of LAMP2 has been implicated in various diseases, including lysosomal storage disorders, neurodegenerative diseases, and certain types of cancer. Therefore, understanding the function of LAMP2 is essential for developing targeted therapies that aim to modulate lysosomal activity and improve cellular health in disease contexts.By using the LAMP2 Polyclonal Antibody (CAB14017), researchers can gain valuable insights into the role of LAMP2 in cellular processes and disease progression, ultimately paving the way for novel therapeutic strategies that target lysosomal function for the treatment of various disorders.
Product Name:
LAMP2 Rabbit Polyclonal Antibody
SKU:
CAB14017
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-375 of human LAMP2 (NP_002285.1).
Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein.
Calculated MW:
45kDa
Observed MW:
100-130kDa
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins.
Purification Method:
Affinity purification
Gene ID:
3920
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] LAMP2 Rabbit pAb (CAB14017) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
