LAMP1 Antibody (CAB2582)
- SKU:
- CAB2582
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Anti-LAMP1 Antibody (CAB2582)
The LAMP1 Polyclonal Antibody (CAB2582) is a valuable tool for researchers studying lysosomal-associated membrane protein 1 (LAMP1), a key marker for lysosomal structures and autophagosomes. This antibody is produced in rabbits and has been validated for use in Western blot applications, providing reliable detection and analysis of LAMP1 in various cell types.LAMP1 is essential for the functioning of lysosomes and autophagosomes, playing a critical role in cellular processes such as protein degradation, lipid metabolism, and antigen presentation. Dysregulation of LAMP1 is implicated in various diseases, including cancer, neurodegenerative disorders, and lysosomal storage diseases.
By targeting LAMP1 with this antibody, researchers can investigate the role of lysosomal structures in disease development and progression, potentially leading to the development of new therapeutic strategies.Overall, the LAMP1 Polyclonal Antibody (CAB2582) is a reliable tool for studying lysosomal-associated membrane protein 1 and its involvement in cellular processes and disease pathology. Its high reactivity with human samples and specificity for LAMP1 make it an ideal choice for research in cell biology, cancer biology, and autophagy-related disorders.
| Antibody Name: | Anti-LAMP1 Antibody |
| Antibody SKU: | CAB2582 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human LAMP1 (NP_005552.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, 293T, BT-474 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human LAMP1 (NP_005552.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CGKE NTSD PSLV IAFG RGHT LTLN FTRN ATRY SVQL MSFV YNLS DTHL FPNA SSKE IKTV ESIT DIRA DIDK KYRC VSGT QVHM NNVT VTLH DATI QAYL SNSS FSRG ETRC EQDR PSPT TAPP APPS PSPS PVPK SPSV DKYN VSGT NGTC LLAS MGLQ LNLT YERK DNTT VTRL LNIN PNKT SASG SCGA HLVT LELH S |
| Gene ID: | 3916 |
| Uniprot: | P11279 |
| Cellular Location: | Cell membrane, Endosome membrane, Late endosome, Lysosome membrane, Single-pass type I membrane protein |
| Calculated MW: | 38kDa/44kDa |
| Observed MW: | 120kDa |
| Synonyms: | LAMP1, CD107a, LAMPA, LGP120 |
| Background: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. |
| UniProt Protein Function: | LAMP1: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Belongs to the LAMP family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 13q34 Cellular Component: integral to plasma membrane; lysosome; dendrite; multivesicular body; cell soma; membrane; late endosome; cytoplasm; plasma membrane; melanosome; endosome membrane; sarcolemma; external side of plasma membrane Molecular Function:protein domain specific binding; protein binding; enzyme binding Biological Process: positive regulation of natural killer cell degranulation; induction of apoptosis by granzyme; protein stabilization; viral reproduction; autophagic cell death; autophagy; positive regulation of natural killer cell mediated cytotoxicity |
| NCBI Summary: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11279 |
| NCBI GenInfo Identifier: | 206729915 |
| NCBI Gene ID: | 3916 |
| NCBI Accession: | P11279.3 |
| UniProt Secondary Accession: | P11279,Q8WU33, Q96I40, Q9BRD2, Q9NP13, B4DWL3, |
| UniProt Related Accession: | P11279 |
| Molecular Weight: | 417 |
| NCBI Full Name: | Lysosome-associated membrane glycoprotein 1 |
| NCBI Synonym Full Names: | lysosomal-associated membrane protein 1 |
| NCBI Official Symbol: | LAMP1Â Â |
| NCBI Official Synonym Symbols: | LAMPA; CD107a; LGP120Â Â |
| NCBI Protein Information: | lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1 |
| UniProt Protein Name: | Lysosome-associated membrane glycoprotein 1 |
| UniProt Synonym Protein Names: | CD107 antigen-like family member A; CD_antigen: CD107a |
| Protein Family: | Lysosome-associated membrane glycoprotein |
| UniProt Gene Name: | LAMP1Â Â |
| UniProt Entry Name: | LAMP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MCL1 antibody (CAB2582) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of HeLa cells using LAMP1 antibody (CAB2582) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using LAMP1 antibody (CAB2582) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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