The LAMP1 Polyclonal Antibody (CAB21481) is specifically designed for research involving LAMP1, a key protein involved in lysosome biogenesis and autophagy. The antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications including Western blot, immunofluorescence, and immunohistochemistry. By binding to the LAMP1 protein, this antibody enables researchers to detect and analyze lysosomal function in a wide range of cell types.LAMP1, also known as lysosomal-associated membrane protein 1, plays a crucial role in maintaining cellular homeostasis by facilitating the fusion of lysosomes with autophagosomes and endosomes.
Dysregulation of LAMP1 function has been linked to various diseases including lysosomal storage disorders, neurodegenerative diseases, and cancer. Therefore, studying the role of LAMP1 in cellular processes is essential for understanding the pathogenesis of these conditions and developing targeted therapies.Overall, the LAMP1 Polyclonal Antibody (CAB21481) provides researchers with a valuable tool for investigating lysosomal biology and exploring the implications of LAMP1 dysfunction in disease states. Its high specificity and sensitivity make it an ideal choice for studies in cell biology, molecular biology, and drug discovery.
Product Name:
LAMP1 Polyclonal Antibody
SKU:
CAB21481
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 29-382 of human LAMP1 (NP_005552.3).
Cell membrane, Endosome membrane, Late endosome, Lysosome membrane, Single-pass type I membrane protein.
Calculated MW:
45kDa
Observed MW:
90-120kDa
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.
Purification Method:
Affinity purification
Gene ID:
3916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from U-937 cells, using [KD Validated] LAMP1 Rabbit pAb (CAB21481) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
