The LAMP1 Polyclonal Antibody (CAB16894) is a valuable tool for researchers studying Lysosome-associated membrane glycoprotein 1 (LAMP1) in various cellular processes. LAMP1 is a key marker for lysosomal compartments and plays a crucial role in regulating lysosomal biogenesis and function. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunofluorescence applications.LAMP1 is essential for maintaining cellular homeostasis by mediating lysosomal fusion and autophagosome-lysosome fusion, processes that are vital for degradation of cellular waste and recycling of cellular components. Dysregulation of LAMP1 has been linked to various diseases, including lysosomal storage disorders, neurodegenerative diseases, and cancer.
Research into the function and regulation of LAMP1 is therefore critical for understanding the molecular mechanisms underlying these pathological conditions and for developing potential therapeutic interventions. By using the LAMP1 Polyclonal Antibody, researchers can accurately detect and analyze LAMP1 expression and localization in different cell types and under various experimental conditions. This antibody is a valuable tool for studies in cell biology, lysosome biology, autophagy, and diseases associated with lysosomal dysfunction.
Product Name:
LAMP1 Rabbit Polyclonal Antibody
SKU:
CAB16894
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human LAMP1 (NP_005552.3).
Cell membrane, Endosome membrane, Late endosome, Lysosome membrane, Single-pass type I membrane protein.
Calculated MW:
45kDa
Observed MW:
110kDa/90-120kDa
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.
Purification Method:
Affinity purification
Gene ID:
3916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using LAMP1 Rabbit pAb (CAB16894) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
