The Lamin B2 Rabbit Monoclonal Antibody (CAB5001) is a specialized tool for researchers studying Lamin B2, a key protein involved in nuclear organization and cell structure. This antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting Lamin B2 in human samples, making it a reliable tool for various applications, including Western blot analysis.Lamin B2 is a crucial component of the nuclear lamina and plays a vital role in maintaining nuclear stability and integrity. Dysregulation of Lamin B2 has been implicated in various diseases, including cancer and genetic disorders.
By targeting Lamin B2 with this antibody, researchers can gain insights into the role of this protein in cellular processes and disease pathogenesis.The Lamin B2 Rabbit Monoclonal Antibody (CAB5001) is an essential resource for researchers interested in investigating the functions and dysregulation of Lamin B2 in disease states. Its specificity and reliability make it a valuable tool for studies in cell biology, cancer research, and other fields where Lamin B2 is a key player.
Product Name:
Lamin B2 Rabbit Monoclonal Antibody
SKU:
CAB5001
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 521-620 of human Lamin B2 (Q03252).
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy.
Purification Method:
Affinity purification
Gene ID:
84823
Clone Number:
ARC1252
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Lamin B2 Rabbit mAb (CAB5001) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
