The Lamin B1 Polyclonal Antibody (ALI20) is an essential tool for researchers studying the nuclear envelope protein Lamin B1. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in various applications such as immunofluorescence, immunohistochemistry, and Western blotting.Lamin B1 is a key component of the nuclear lamina, playing a crucial role in maintaining nuclear structure and function. Dysregulation of Lamin B1 has been implicated in various diseases, including cancer and progeria.
By targeting Lamin B1, researchers can investigate its role in nuclear organization, gene regulation, and cell differentiation.This antibody enables researchers to accurately detect and analyze Lamin B1 in different cell types and tissue samples, making it a valuable tool for studies in cell biology, cancer research, and developmental biology. Understanding the function of Lamin B1 is essential for unraveling its contributions to disease pathogenesis and identifying potential therapeutic targets.
Product Name:
Lamin B1 Polyclonal Antibody
SKU:
CAB2452
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 400-500 of human Lamin B1 (NP_005564.1).
Sequence:
VSRA SSSR SVRT TRGK RKRV DVEE SEAS SSVS ISHS ASAT GNVC IEEI DVDG KFIR LKNT SEQD QPMG GWEM IRKI GDTS VSYK YTSR YVLK AGQT VTIW A
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4001
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using Lamin B1 Rabbit pAb (CAB2452).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
