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LAMC1 Rabbit Polyclonal Antibody (CAB16020)

SKU:
CAB16020
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 6 Anti-LAMC1 Antibody CAB16020
  • Cell Biology Antibodies 6 Anti-LAMC1 Antibody CAB16020
  • Cell Biology Antibodies 6 Anti-LAMC1 Antibody CAB16020
  • Cell Biology Antibodies 6 Anti-LAMC1 Antibody CAB16020
  • Cell Biology Antibodies 6 Anti-LAMC1 Antibody CAB16020
€139 - €419
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Description

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LAMC1 Rabbit Polyclonal Antibody (CAB16020)

The LAMC1 Polyclonal Antibody (CAB16020) is a valuable tool for researchers studying LAMC1, a key component of the extracellular matrix and basement membranes. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the LAMC1 protein, researchers can accurately detect and analyze its expression in a variety of cell types.LAMC1, also known as laminin subunit gamma-1, plays a crucial role in maintaining tissue architecture and function. Dysregulation of LAMC1 has been associated with various diseases, including cancer, muscular dystrophy, and kidney disorders.

By studying the expression and function of LAMC1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the LAMC1 Polyclonal Antibody is an essential tool for investigating the role of LAMC1 in health and disease. Its high reactivity and specificity make it ideal for use in immunology and cancer research, as well as in studies focusing on tissue development and regeneration.

Product Name:LAMC1 Rabbit Polyclonal Antibody
SKU:CAB16020
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1275 of human LAMC1 (NP_002284.3).
Sequence:ECPA CYRL VKDK VADH RVKL QELE SLIA NLGT GDEM VTDQ AFED RLKE AERE VMDL LREA QDVK DVDQ NLMD RLQR VNNT LSSQ ISRL QNIR NTIE ETGN LAEQ ARAH VENT ERLI EIAS RELE KAKV AAAN VSVT QPES TGDP NNMT LLAE EARK LAER HKQE ADDI VRVA KTAN DTST EAYN LLLR TLAG ENQT AFEI EELN RKYE QAKN ISQD LEKQ AARV HEEA KRAG DKAV EIYA SVAQ LS
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200
Synonyms:LAMB2; LAMC1
Positive Sample:LO2,Mouse heart,Mouse kidney,Rat heart
Conjugate:Unconjugated
Cellular Localization:basement membrane, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space
Calculated MW:178kDa
Observed MW:220kDa

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.

Purification Method:Affinity purification
Gene ID:3915
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using LAMC1 Rabbit pAb (CAB16020) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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