LAMB4 Antibody (PACO63339)
- SKU:
- PACO63339
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
LAMB4 Antibody (PACO63339)
The LAMB4 Polyclonal Antibody (PAC06339) is a valuable tool for researchers investigating LAMB4, a protein involved in cell adhesion and migration processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the LAMB4 protein, this antibody allows for the accurate detection and analysis of LAMB4 levels in various cell types, making it an essential component for studies in cell biology and cancer research.
LAMB4, also known as laminin subunit beta 4, is a key player in the formation and maintenance of basement membranes, which are crucial for tissue structure and function. Dysregulation of LAMB4 has been associated with various diseases, including cancer and genetic disorders affecting basement membrane integrity. Research into the function of LAMB4 is essential for gaining insights into these conditions and developing potential therapeutic interventions targeting this protein.
| Antibody Name: | LAMB4 Antibody (PACO63339) |
| Antibody SKU: | PACO63339 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Laminin subunit beta-4 protein (1513-1761AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63339 diluted at 1:100 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | Immunofluorescence staining of A549 cells with PACO63339 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | IHC image of PACO63339 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Synonyms: | Laminin subunit beta-4 (Laminin beta-1-related protein), LAMB4 |
| UniProt Protein Function: | LAMB4: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q31.1 Cellular Component: basement membrane Biological Process: cell adhesion |
| UniProt Code: | A4D0S4 |
| NCBI GenInfo Identifier: | 968121869 |
| NCBI Gene ID: | 22798 |
| NCBI Accession: | NP_001304975.1 |
| UniProt Secondary Accession: | A4D0S4,Q86TP7, Q86XN2, Q8NBX5, A5PKU6, B2RTT3, B5MEB9 |
| UniProt Related Accession: | A4D0S4 |
| Molecular Weight: | |
| NCBI Full Name: | laminin subunit beta-4 isoform 1 |
| NCBI Synonym Full Names: | laminin subunit beta 4 |
| NCBI Official Symbol: | LAMB4Â Â |
| NCBI Protein Information: | laminin subunit beta-4 |
| UniProt Protein Name: | Laminin subunit beta-4 |
| UniProt Synonym Protein Names: | Laminin beta-1-related protein |
| Protein Family: | Laminin |
| UniProt Gene Name: | LAMB4Â Â |
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