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LAMA5 Antibody (PACO02865)

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SKU:
PACO02865
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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LAMA5 Antibody (PACO02865)

The LAMA5 Polyclonal Antibody (PAC002865) is a valuable tool for research involving LAMA5, a protein found in the extracellular matrix of various tissues. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the LAMA5 protein, allowing for detection and analysis in a variety of cell types, making it ideal for studies in cell biology, tissue development, and cancer research.LAMA5, also known as laminin alpha 5, plays a crucial role in cell adhesion, migration, and tissue organization. Its involvement in basement membrane formation and maintenance makes it a key player in processes such as angiogenesis and wound healing.

Research into LAMA5 can provide insights into various diseases, including cancer, muscular dystrophy, and kidney disorders, where aberrant expression or function of this protein may contribute to pathogenesis.By utilizing the LAMA5 Polyclonal Antibody, researchers can further investigate the functions and regulatory mechanisms of LAMA5 in different biological contexts. Understanding the role of LAMA5 in normal physiology and disease states is essential for the development of targeted therapies and diagnostic strategies in various medical fields.

Antibody Name:LAMA5 Antibody
Antibody SKU:PACO02865
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human Laminin alpha-5.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:LAMA5; KIAA0533; KIAA1907; Laminin subunit alpha-5; Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha
UniProt Protein Function:LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Extracellular matrix; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.2-q13.3

Cellular Component: extracellular matrix; extracellular space; laminin-5 complex; laminin-1 complex; laminin-10 complex; extracellular region; basement membrane; basal lamina; nucleus

Molecular Function:integrin binding; structural molecule activity

Biological Process: integrin-mediated signaling pathway; regulation of cell adhesion; focal adhesion formation; endothelial cell differentiation; extracellular matrix organization and biogenesis; muscle development; cell migration; regulation of embryonic development; cell recognition; cytoskeleton organization and biogenesis; regulation of cell migration; regulation of cell proliferation; odontogenesis of dentine-containing teeth; cell proliferation; extracellular matrix disassembly; embryonic development; morphogenesis of embryonic epithelium; hair follicle development; ureteric bud branching; cilium biogenesis; angiogenesis; cell differentiation; neural crest cell migration; morphogenesis of a polarized epithelium; lung development

NCBI Summary:This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
UniProt Code:O15230
NCBI GenInfo Identifier:21264602
NCBI Gene ID:3911
NCBI Accession:
UniProt Related Accession:O15230
Molecular Weight:
NCBI Full Name:laminin subunit alpha-5
NCBI Synonym Full Names:laminin subunit alpha 5
NCBI Official Symbol:LAMA5  
NCBI Protein Information:laminin subunit alpha-5
UniProt Protein Name:Laminin subunit alpha-5
UniProt Synonym Protein Names:Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha
UniProt Gene Name:LAMA5  
UniProt Entry Name:LAMA5_HUMAN

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