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LAMA4 Rabbit Polyclonal Antibody (CAB15286)

SKU:
CAB15286
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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LAMA4 Rabbit Polyclonal Antibody (CAB15286)

The LAMA4 Polyclonal Antibody (CAB15286) is a valuable tool for researchers studying LAMA4, a key component of the extracellular matrix involved in cell adhesion and migration processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is ideal for use in Western Blot applications. By binding specifically to the LAMA4 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in cancer biology, tissue development, and cell signaling pathways.LAMA4, also known as laminin alpha-4, plays a crucial role in controlling cell behavior and tissue organization, making it a promising target for research on diseases such as cancer, developmental disorders, and inflammation.

Understanding the function and regulation of LAMA4 is essential for uncovering its role in pathophysiological processes and identifying potential therapeutic strategies for related conditions. The LAMA4 Polyclonal Antibody is a reliable tool for investigating LAMA4 expression levels and localization, furthering our understanding of its biological functions and potential clinical implications.

Product Name:LAMA4 Rabbit Polyclonal Antibody
SKU:CAB15286
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LAMA4 (NP_001098678.1).
Sequence:MALS SAWR SVLP LWLL WSAA CSRA ASGD DNAF PFDI EGSS AVGR QDPP ETSE PRVA LGRL PPAA EVQC PCHC HPAG APAP PRAV PHSS FSLS PPLS SPQC
Tested Applications:WB ELISA
Recommended Dilution:WB,1:200 - 1:2000
Synonyms:LAMA3; CMD1JJ; LAMA4*-1; LAMA4
Positive Sample:293T
Conjugate:Unconjugated
Cellular Localization:Secreted, basement membrane, extracellular matrix, extracellular space.
Calculated MW:203kDa
Observed MW:203kDa

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Purification Method:Affinity purification
Gene ID:3910
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from 293T cells, using LAMA4 Rabbit pAb (CAB15286) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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