The LAMA2 Polyclonal Antibody (PACO4207) is a valuable tool for research involving LAMA2, a key component of the extracellular matrix found in muscle tissue. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is well-suited for use in Western blot applications. By binding to the LAMA2 protein, this antibody enables the detection and analysis of LAMA2 in various cell types, making it an ideal choice for studies relating to muscular dystrophy, muscle development, and extracellular matrix biology.LAMA2, also known as laminin alpha-2, plays a crucial role in maintaining the structural integrity of muscle tissue and is associated with congenital muscular dystrophy.
Research on LAMA2 is essential for gaining insights into the pathogenesis of muscular disorders and exploring potential therapeutic strategies. By investigating the function and regulation of LAMA2, scientists can advance their understanding of muscle biology and contribute to the development of novel treatments for muscle-related diseases.Overall, the LAMA2 Polyclonal Antibody (PACO4207) offers researchers a reliable tool for studying the role of LAMA2 in muscle biology and disease, with the potential to contribute to significant advancements in the field of muscular dystrophy research.
Antibody Name:
LAMA2 Antibody
Antibody SKU:
PACO04207
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human Laminin alpha-2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
LAMA2; LAMM; Laminin subunit alpha-2; Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain
UniProt Protein Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
UniProt Protein Details:
NCBI Summary:
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
