LAMA1 Antibody (PACO22064)
- SKU:
- PACO22064
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
LAMA1 Antibody (PACO22064)
The Lama1 Antibody (PACO22064) is a polyclonal antibody designed for research involving Lama1, a key protein involved in cell adhesion and migration. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it an ideal tool for studying Lama1 expression and function.Lama1 is an important component of the extracellular matrix and plays a critical role in tissue development and maintenance. Dysregulation of Lama1 has been associated with various diseases, including cancer, cardiovascular disorders, and muscular dystrophy. By using the Lama1 Antibody, researchers can investigate the role of Lama1 in normal physiological processes and disease pathogenesis.
This antibody is validated for use in Western blot applications, enabling detection and analysis of Lama1 expression in different cell types and tissues. By studying the expression levels and localization of Lama1, researchers can gain insights into its role in cell adhesion, migration, and overall tissue function.Overall, the Lama1 Antibody is a valuable tool for researchers in the fields of cell biology, developmental biology, and disease research. Its high specificity and reactivity with human samples make it a reliable choice for studies aimed at understanding the role of Lama1 in health and disease.
| Antibody Name: | LAMA1 Antibody (PACO22064) |
| Antibody SKU: | PACO22064 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:100-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human LAMA1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence analysis of COS-7 cells, using LAMA1 antibody. |
| Background: | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Synonyms: | LAMA; laminin A; laminin alpha-1; |
| UniProt Protein Function: | LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 18p11.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; laminin-1 complex; laminin-3 complex; extracellular region; basement membrane; intercellular junction Molecular Function:protein binding; extracellular matrix structural constituent; glycosphingolipid binding; receptor binding Biological Process: regulation of cell adhesion; axon guidance; extracellular matrix organization and biogenesis; cell surface receptor linked signal transduction; regulation of embryonic development; morphogenesis of an epithelial sheet; establishment of epithelial cell polarity; cell adhesion; regulation of cell migration Disease: Poretti-boltshauser Syndrome |
| NCBI Summary: | This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P25391 |
| NCBI GenInfo Identifier: | 38788416 |
| NCBI Gene ID: | 284217 |
| NCBI Accession: | NP_005550.2 |
| UniProt Related Accession: | P25391 |
| Molecular Weight: | 337,084 Da |
| NCBI Full Name: | laminin subunit alpha-1 |
| NCBI Synonym Full Names: | laminin, alpha 1 |
| NCBI Official Symbol: | LAMA1Â Â |
| NCBI Official Synonym Symbols: | LAMA; PTBHS; S-LAM-alpha  |
| NCBI Protein Information: | laminin subunit alpha-1; S-LAM alpha; S-laminin subunit alpha; laminin A chain; laminin-3 subunit alpha |
| UniProt Protein Name: | Laminin subunit alpha-1 |
| UniProt Synonym Protein Names: | Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha |
| Protein Family: | Laminin |
| UniProt Gene Name: | LAMA1Â Â |
| UniProt Entry Name: | LAMA1_HUMAN |
| Antibodies | ELISA Kits |
| LAMA1 Antibody (PACO03931) | Human Laminin subunit alpha-1 / LAMA1 ELISA Kit |
| Human Laminin subunit alpha-1 (LAMA1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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