LAMA1 Antibody (PACO18157)
- SKU:
- PACO18157
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
LAMA1 Antibody (PACO18157)
The LAMA1 Polyclonal Antibody (PAC018157) is a valuable tool for research involving LAMA1, a key protein in the extracellular matrix of cells. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the LAMA1 protein, this antibody enables the detection and analysis of LAMA1 in various cell types, making it ideal for studies in cell biology and tissue development.LAMA1, also known as laminin alpha 1, is involved in cell adhesion, migration, and differentiation, playing a crucial role in various physiological processes such as tissue repair and development.
Dysregulation of LAMA1 has been associated with diseases like muscular dystrophies, cancer, and kidney disorders. Therefore, studying the function of LAMA1 with this antibody can provide insights into these pathological conditions and potentially lead to the development of targeted therapies.Overall, the LAMA1 Polyclonal Antibody (PAC018157) offers researchers a reliable tool for investigating the role of LAMA1 in cellular processes and disease pathogenesis, paving the way for advancements in biomedical research and therapeutic interventions.
| Antibody Name: | LAMA1 Antibody (PACO18157) |
| Antibody SKU: | PACO18157 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human LAMA1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18157(LAMA1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18157(LAMA1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Synonyms: | laminin, α 1 |
| UniProt Protein Function: | LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 18p11.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; laminin-1 complex; laminin-3 complex; extracellular region; basement membrane; intercellular junction Molecular Function:protein binding; extracellular matrix structural constituent; glycosphingolipid binding; receptor binding Biological Process: regulation of cell adhesion; axon guidance; extracellular matrix organization and biogenesis; cell surface receptor linked signal transduction; regulation of embryonic development; morphogenesis of an epithelial sheet; establishment of epithelial cell polarity; cell adhesion; regulation of cell migration Disease: Poretti-boltshauser Syndrome |
| NCBI Summary: | This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P25391 |
| NCBI GenInfo Identifier: | 38788416 |
| NCBI Gene ID: | 284217 |
| NCBI Accession: | NP_005550.2 |
| UniProt Related Accession: | P25391 |
| Molecular Weight: | 337,084 Da |
| NCBI Full Name: | laminin subunit alpha-1 |
| NCBI Synonym Full Names: | laminin, alpha 1 |
| NCBI Official Symbol: | LAMA1Â Â |
| NCBI Official Synonym Symbols: | LAMA; PTBHS; S-LAM-alpha  |
| NCBI Protein Information: | laminin subunit alpha-1; S-LAM alpha; S-laminin subunit alpha; laminin A chain; laminin-3 subunit alpha |
| UniProt Protein Name: | Laminin subunit alpha-1 |
| UniProt Synonym Protein Names: | Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha |
| Protein Family: | Laminin |
| UniProt Gene Name: | LAMA1Â Â |
| UniProt Entry Name: | LAMA1_HUMAN |
| Antibodies | ELISA Kits |
| LAMA1 Antibody (PACO03931) | Human Laminin subunit alpha-1 / LAMA1 ELISA Kit |
| Human Laminin subunit alpha-1 (LAMA1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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Human Laminin subunit alpha-1 (LAMA1) ELISA Kit (HUEB0424)
