LAMA1 Antibody (PACO03931)
- SKU:
- PACO03931
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
LAMA1 Antibody (PACO03931)
The LAMA1 Polyclonal Antibody (PACO03931) is a valuable tool for researchers studying LAMA1, a cell adhesion glycoprotein that plays a key role in the integrity of the extracellular matrix.This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the LAMA1 protein, it allows for the precise detection and analysis of LAMA1 in various cell types.
Given the importance of LAMA1 in maintaining tissue structure and function, this antibody is ideal for investigations in fields such as cell biology, tissue engineering, and cancer research. Understanding the role of LAMA1 can lead to insights into disease mechanisms and the development of targeted therapies for conditions related to extracellular matrix dysfunction.
| Antibody Name: | LAMA1 Antibody |
| Antibody SKU: | PACO03931 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | IF:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the C-terminal region of human Laminin alpha-1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | LAMA1; LAMA; Laminin subunit alpha-1; Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha |
| UniProt Protein Function: | LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 18p11.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; laminin-1 complex; laminin-3 complex; extracellular region; basement membrane; intercellular junction Molecular Function:protein binding; extracellular matrix structural constituent; glycosphingolipid binding; receptor binding Biological Process: regulation of cell adhesion; axon guidance; extracellular matrix organization and biogenesis; cell surface receptor linked signal transduction; regulation of embryonic development; morphogenesis of an epithelial sheet; establishment of epithelial cell polarity; cell adhesion; regulation of cell migration Disease: Poretti-boltshauser Syndrome |
| NCBI Summary: | This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P25391 |
| NCBI GenInfo Identifier: | 38788416 |
| NCBI Gene ID: | 284217 |
| NCBI Accession: | NP_005550.2 |
| UniProt Related Accession: | P25391 |
| Molecular Weight: | 337,084 Da |
| NCBI Full Name: | laminin subunit alpha-1 |
| NCBI Synonym Full Names: | laminin, alpha 1 |
| NCBI Official Symbol: | LAMA1Â Â |
| NCBI Official Synonym Symbols: | LAMA; PTBHS; S-LAM-alpha  |
| NCBI Protein Information: | laminin subunit alpha-1; S-LAM alpha; S-laminin subunit alpha; laminin A chain; laminin-3 subunit alpha |
| UniProt Protein Name: | Laminin subunit alpha-1 |
| UniProt Synonym Protein Names: | Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha |
| Protein Family: | Laminin |
| UniProt Gene Name: | LAMA1Â Â |
| UniProt Entry Name: | LAMA1_HUMAN |
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