The LAG3 Polyclonal Antibody (CAB2996) is specifically designed for research involving Lymphocyte-activation gene 3 (LAG3), a protein known for its role in immune regulation and maintaining immune tolerance. This antibody, produced in rabbits, offers high reactivity with human samples and has been validated for use in Western blot applications. By binding to the LAG3 protein, this antibody allows for the detection and analysis of LAG3 in various cell types, making it ideal for studies in immunology and cancer research.LAG3 is a key player in immune response modulation, functioning as an immune checkpoint receptor that downregulates T-cell activation and dampens immune responses. Its involvement in immune regulation makes LAG3 a promising target for research related to cancer immunotherapy, autoimmune diseases, and other immune-related conditions.
Understanding the mechanisms of LAG3 activity is essential for the development of therapeutic strategies that manipulate immune responses in different disease contexts.Overall, the LAG3 Polyclonal Antibody (CAB2996) serves as a valuable tool for researchers interested in dissecting the function of LAG3 and its implications in immune modulation. With its high specificity and reactivity, this antibody enables precise detection and analysis of LAG3 protein levels, facilitating deeper insights into immune regulation and potential therapeutic targets.
Product Name:
LAG3 Rabbit Polyclonal Antibody
SKU:
CAB2996
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-170 of human LAG3 (NP_002277.4).
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
Purification Method:
Affinity purification
Gene ID:
3902
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LAG3 antibody (CAB2996) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
