EPM2A Rabbit Polyclonal Antibody (CAB7007)
- SKU:
- CAB7007
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
Product Name: | EPM2A Rabbit Polyclonal Antibody |
SKU: | CAB7007 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 244-331 of human EPM2A (NP_005661.1). |
Sequence: | MLPQ AVCL LHAL LEKG HIVY VHCN AGVG RSTA AVCG WLQY VMGW NLRK VQYF LMAK RPAV YIDE EALA RAQE DFFQ KFGK VRSS VCSL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | EPM2; MELF; EPM2A |
Positive Sample: | HeLa,Mouse brain,Mouse heart,Mouse testis,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 37kDa |
Observed MW: | 37kDa |
This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Loss-of-function mutations in this gene have been associated with Lafora disease, a rare, adult-onset recessive neurodegenerative disease, which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of insoluble particles called Lafora bodies, which are derived from glycogen.
Purification Method: | Affinity purification |
Gene ID: | 7957 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |