The L3MBTL3 Polyclonal Antibody (CAB7289) is a valuable tool for researchers studying L3MBTL3, a protein involved in gene regulation and chromatin remodeling. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By binding to L3MBTL3, the antibody enables accurate detection and analysis of this protein in various cell types, facilitating studies in epigenetics and cancer research.
L3MBTL3, a member of the polycomb group (PcG) protein family, is known for its role in histone methylation and transcriptional regulation. Dysregulation of L3MBTL3 has been implicated in various diseases, including cancer, developmental disorders, and neurological conditions. By exploring the functions of L3MBTL3, researchers can gain insights into the mechanisms underlying these pathologies and potentially identify novel therapeutic targets for intervention.
Product Name:
[KO Validated] L3MBTL3 Rabbit Polyclonal Antibody
SKU:
CAB7289
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human L3MBTL3 (NP_115814.1).
This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma.
Purification Method:
Affinity purification
Gene ID:
84456
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using L3MBTL3 Rabbit pAb (CAB7289) at 1:4000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
