The L2HGDH Polyclonal Antibody (CAB7996) is a valuable tool for researchers studying L2HGDH, an enzyme involved in the metabolism of L-2-hydroxyglutaric acid. This antibody, raised in rabbits, is highly specific and reacts with human samples, making it suitable for a variety of research applications, particularly in the field of metabolism and metabolic disorders.L2HGDH is an important enzyme that plays a role in maintaining cellular metabolism and energy production. Mutations in the L2HGDH gene have been associated with L-2-hydroxyglutaric aciduria, a rare metabolic disorder characterized by elevated levels of L-2-hydroxyglutaric acid in the urine.
Research into the function and regulation of L2HGDH is essential for understanding the underlying mechanisms of this disorder and developing potential treatments.Using the L2HGDH Polyclonal Antibody, researchers can detect and analyze the expression of L2HGDH in various cell types and tissues, providing valuable insights into its role in metabolism and potential implications in disease. This antibody is validated for use in Western blot applications, making it a reliable tool for studying L2HGDH in both basic and clinical research settings.
Product Name:
L2HGDH Rabbit Polyclonal Antibody
SKU:
CAB7996
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human L2HGDH (NP_079160.1).
This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe cognitive disability.
Purification Method:
Affinity purification
Gene ID:
79944
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using L2HGDH antibody (CAB7996) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
