The L2HGDH Polyclonal Antibody (CAB15192) is a valuable tool for research involving L2HGDH, a key enzyme involved in metabolizing L-2-hydroxyglutarate, a metabolite implicated in various diseases, including cancer. The antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the L2HGDH protein, this antibody enables the detection and analysis of L2HGDH in cell samples, making it an indispensable tool for researchers studying metabolism, cancer biology, and other related fields.L2HGDH is a crucial enzyme in the maintenance of cellular metabolism, and dysregulation of its activity has been associated with the development and progression of cancer.
By targeting L2HGDH, researchers can gain insights into the metabolic pathways underlying cancer development and potentially identify new therapeutic approaches targeting this enzyme. The L2HGDH Polyclonal Antibody offers researchers a powerful tool to further investigate the role of L2HGDH in disease pathogenesis, opening up new possibilities for targeted therapies and precision medicine approaches.
Product Name:
L2HGDH Rabbit Polyclonal Antibody
SKU:
CAB15192
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human L2HGDH (NP_079160.1).
This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe cognitive disability.
Purification Method:
Affinity purification
Gene ID:
79944
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse heart, using L2HGDH Rabbit pAb (CAB15192) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
